For glucose control Bariatric Surgery better than diet

Researchers at the Hospital Center, Columbia University, Duke University Medical Center and St. Luke's and Roosevelt have a new idea why bariatric surgery is more effective than dietary alone resolves to control blood sugar levels revealed.

This discovery and facts from their previous studies obtained provide even more evidence that branched amino acids biomarkers are making the careful consideration in the development and treatment of diabetes.

Doctors have observed that bariatric surgery leads to improved blood sugar levels up to 80 percent of cases, but the reason was not very clear. Although the success that improves gastric bypass surgery (GBP) glucose control in type 2 diabetes before significant weight loss suggests the alternative mechanisms relating to biochemical and/or hormonal changes occurred significant weight loss part,.

The current study showed that obese people with type 2 diabetes is a GBP surgery have much lower levels of circulating branched-chain amino acids (BCAA) and the aromatic amino acids phenylalanine (PHE) and tyrosine (Tyr), compared to a matched group of obese patients with diabetes, an equal amount of weight lost on the basis of a diet.

The results were published on April 27 in science translational medicine.

This improves decrease BCAA and aromatic amino acids PHE and Tyr was combined with better improve of glycemic (blood sugar) in the Group of GBP.

Lead author Blandine Laferrere, m.d., of the New York obesity Nutrition Research Center (NYONRC) at the St. Luke's and Roosevelt a cohort of patients provided for a group of obese patients without diabetes provided Hospital Center, comparison, and Duke University, in GBP and diet voted groups for review. The preferential reduction showed both types of results in amino and acids in the subjects of GBP, correlates to better blood sugar control.

"The most fascinating finding that amino acids, especially the branched-chain amino acids, decreased significantly more after gastric bypass surgery than for the same weight loss by intervention from the current study, diet", said Dr. Laferrere. "The next step will be to characterize the way these metabolic changes involved, so we can understand, such as the specific metabolic signature of gastric bypass surgery action, including good hormones that occur after the operation is associated with changes in hormones and hormone."

Senior author Christopher B. Newgard, PhD., and colleagues at the Sarah W. Stedman Nutrition and Metabolism Center at Duke University, evaluated copies of Centre metabolic profiling Laboratory ("metabolomics"). The Centre of laboratory uses mass spectrometry to measure hundreds of metabolic intermediates at the same time in simple blood tests.

In earlier studies by the Group of the Duke and his associates, cluster branched-chain amino acids have been PHE, Tyr and the degradation products of the BCAAs associated with insulin resistance in three independent studies of the people, and also with coronary heart disease in a separate case control study.

"The evidence piling up the BCAA and related metabolites with insulin resistance and diabetes are connected, and the metabolic dysfunction may cause she", said Newgard. "The current study shows that these metabolites also quickly reagierende a very effective diabetes intervention, stomach are bypass surgery."

An independent study, published in March of this year by a group of Harvard/broad Institute topics from the Framingham Heart study shows that branched and aromatic amino acids serve as a biomarker for risk of type 2 diabetes.

"Progress, we must completely studies in the general population to the value of the amino acid signature in models of risk and come with clinically valuable algorithms design", Newgard said. "We must also understand how BCAA and related metabolites in patients at risk for diabetes - levied these genetics, diet, gut bacteria or is a combination of these factors?"

The study of the American Diabetes was supported by grants from the National Institute of health, Association, Glaxo SmithKline and an Institute of mental health scholarship.

Source:
Mary Jane Gore
Duke University Medical Center

source:medicalnewstoday