Activation of biomarker appears associated with improved survival among obese patients with colorectal cancer

Among obese patients activation of protein biomarkers CTNNB1 was associated with better colorectal cancer specific survival and overall survival, while post-diagnosis physical activity associated with better colorectal cancer specific survival in patients negative for CTNNB1, was a study in the April 27 issue of JAMA.

Activation of the WNT signaling pathway (a network of proteins, known for her roles in cancer) and cadherin-associated protein beta-1 (CTNNB1;) [Beta-catenin]) plays an important role in colorectal carcinogenesis. A role of WNT CTNNB1 are accumulable evidence signalling in obesity and metabolic diseases, according to background information in the article. Considering that the dual role of CTNNB1 in carcinogenesis and energy metabolism, the authors the hypothesis, that WNT CTNNB1 proliferative ability could signal activation, give cancer cells. "Furthermore, epidemiological evidence of causal effects of obesity or excess energy balance on colon cancer incidence and mortality suggests." In particular physical activity (exercise) emerged as factor who survive cancer, can improve modifiable lifestyle "Write the authors."

Teppei Morikawa, m.d., PhD., of the Dana-Farber Cancer Institute, Boston, and colleagues led a study to examine whether CTNNB1 prognostic associations of body mass activation in colorectal cancer index (BMI) and postdiagnosis physical activity changed. The study included data from 2 U.S. prospective cohort studies (nurses' health study and the health professionals follow-up study) evaluate CTNNB1 955 patients with stage I, II, III or IV colon and rectal cancer from 1980 to 2004. A model was used to the risk of death, adaptation for clinical and tumor features charge.

While follow up to June 2009 were 440 deaths, containing 266 colorectal cancer-specific deaths. Impact of BMI analysis indicated there was significant change. In obese patients (BMI of 30 or greater), positive status for nuclear CTNNB1 was significantly better colorectal cancer-specific survival associated with (5-year survival rate: 0.85 for patients with positive nuclear CTNNB1 status vs. 0.78 for those with negative status) as well as the overall survival (5-year Ueberlebensrate0), 77 for patients with positive nuclear CTNNB1 status vs. 0.74 for those with negative status). On the other hand not cancer-specific survival or overall survival was significantly associated with nonobese patients, positive status for nuclear CTNNB1.

The authors also found that in patients with negative status for nuclear CTNNB1, high postdiagnosis physical activity significantly better colorectal cancer specific survival (5-year survival rate, 0.97 vs. 0.89) associated with. In patients with positive status for CTNNB1, physical activity was however not associated with colorectal cancer specific survival or overall survival.

"These results demonstrate for a possible interactive effect of CTNNB1 signal tumor and patient energy balance status in tumor cell behavior determine." Our data support the hypothesis that progression of a tumor with one might be influenced inactive CTNNB1 WNT pathway energy intake and expenditure, while a tumor with an active WNT CTNNB1 signaling pathway regardless of energy balance status progress could. Although our data must be confirmed by independent records, tumor CTNNB1 can be used as predictive biomarkers for the response to a prescription for physical activity (exercise) in clinical practice status. Because physical activity is a modifiable lifestyle factor, our data significant clinical effects can have, ", the authors write."

JAMA. 2011; 305 [16] 1685-1694.

source:medicalnewstoday