Wednesday, April 27 HealthDay News)-gastric bypass surgery has been known to improve blood sugar control, sending people with type 2 diabetes often in remission, but experts have long wondered exactly like that happens.
Now, a new study provides some guidance.
Circulating amino acids dramatically linked discovered researchers with insulin resistance decline in those who have the bypass operation. Compare 10 obese people with diabetes, which had the operation with 11 who lost weight by diet.
"Something after gastric bypass that not happening so much after the diet induced weight loss happens", said Dr. Blandine Laferrere, Associate Professor of medicine at St. Luke's Roosevelt Hospital Center and Columbia University, both in New York City.
The study is published in the April 27 issue of science translational medicine.
The transition between the stomach and intestines changes the operation, which reduces the stomach to the size of a small bag. It leads to a drastic reduction in the level of circulating amino acids, which are associated with diabetes.
"The fact that the gastric bypass causes the remission of sin, diabetes in the majority of patients not new", said Laferrere. To go background information in the study of 50 to 80 percent of diabetes cases in remission after surgery.
What have doctors trying to figure out, she said therefore the bypass surgery is so good to make that diabetes disappear. "The diabetes almost immediately improved before a significant amount of weight loss occurs," she said. "That it underlined is something other than weight loss."
In the new study, researchers reviewed biochemical compounds of metabolic reactions in the participants involved. Each group had lost about 20 pounds.
The investigators found that the bypass patients had referred to much lower levels of amino acids as branched-chain amino acids, and the amino acids phenylalanine and tyrosine.
"These changes in the amino acids in the mechanism of diabetes remission may be involved after gastric bypass," said Laferrere.
Experts know that the amino acids with insulin resistance are partially linked through animal studies, she said. "If you supplement the diet of rats with branched-chain amino acids, you more insulin resistance can cause," she explained.
Laferrere said the finding does not mean however that all obese people with diabetes should choose surgery on diets. The operation is very invasive, she mentioned, and not everyone is a candidate.
While fascinating, she said the results are, it is too early to their application on diabetes treatment. Finally, she added, after experts, understand more about the effects that the amino acids, can operation it possible, the results of development to apply diabetes treatments or a less invasive surgery be better.
The new study adds to the weight of other research will find a link between the decline of branched-chain amino acids and the decrease in insulin resistance, said Dr. Thomas j. Wang, Associate Professor of medicine at Harvard Medical School and co-author of the perspective to accompany the study.
"It is known that the gastric bypass quickly insulin resistance, which is one of the most important biochemical anomalies that precedes diabetes," said Wang.
He said "This study really helps to confirm this hypothesis, go below more people branched-chain amino acids that have the weight loss surgery,". While support gives you the idea that there is a connection between the decline of the amino acids and the decrease in insulin resistance, not proves it still cause and effect, Wang added.
"It shows that people, the weight loss surgery have received a larger drop in their branched-chain amino acids." What is still to be proven is whether this decline of branched-chain amino acids is the reason rejects their insulin resistance, "he pointed out."
Wang and his co-author, Dr. Robert Gerszten, is a co-inventor on patent applications related to metabolite predictors for diabetes.
Wang and Gerszten also stressed that the number of obese people diabetes was worldwide 171 million in the year 2000 with type 2. This number is expected to double by 2030. She wrote, a detailed understanding of the role of amino acids in diabetes would be so valuable.
By Kathleen Doheny
More information
To learn more about gastric bypass surgery, please visit the U.S. National Library of medicine.
source:Weight Loss -Nutrition
Tidak ada komentar:
Posting Komentar