The exact location in the brain the nicotine's appetite suppressing effects foot take smokers tend to be thinner than non-smokers and new research shows. The results could be made usable and used as a weight-loss treatment, the researchers say.
The researchers found that nicotine, binds the study said some brain cells a receptor on the surface. If you turn this receptor in mice, the mice of less Aß. The researchers hope that the results will be transmitted to humans.
A treatment on the basis of these results could stop smokers common fear to dispel that weight gain brings, and could potentially complement the weight loss efforts of non-smokers.
"What we find out has been where in the brain [appetite suppression] happens, and find the receptors in the brain that are responsible for nicotine" said study author Marina Picciotto, Professor of Psychiatry at Yale University. "I am confident that we can thus drugs based on these nicotine receptors could be helpful in controlling appetite."
In the study, researchers genes for nicotine manipulated receptors in the brain of the mouse. Disable changing of genes to different receptors in different mice, could they suppress locate responsible to the Group of nicotine receptors for appetite - a group known as [alpha] 3 [beta] 4.
The researchers of mouse model moved commending the accuracy achieved it.
"What I most impressed here was the precision with which they receptor find subunits the nicotine that arrived, were," said Elissa Chesler, a Neurogeneticist at the Jackson Laboratory in Bar Harbor, Maine, who was involved with the study. "If we can this way... maybe we can give people something to control appetite is associated with the dependency of a harmful substance."
She said that probably would transfer results to people as in our cells, the processes at work in mice are very similar.
Picciotto said that future research in the field could help to use suppression of the functioning of the receptors to appetite, to develop a better understanding.
To the possibilities, drug development some potential treatments already up, possibly Picciotto said MyHealthNewsDaily.
"It may be that things already used for smoking cessation in humans could be exploited," she said.
For example, she pointed herbal supplement to Tabex, used in Eastern Europe for smoking cessation, but not in the United States.
They however to note that human resources in research on these receptors tricky, the fight-or flight response involved, and so enable proves, she can increase heart rate and blood pressure.
"It not simple receptor can be objective," she said.
Picciotto said optimistically that research in this area can help some people to, but is not a solution for those looking for a drug to help lose weight. Smokers are usually to gain an average of five and a half pounds, if they stop, she said, and the benefits of a drug would probably in this area.
"It is not obesity with all means to solve," she said.
"Could it helpful for people trying to quit smoking but are concerned about weight gain but it can also help people, that a further instrument to control appetite help need", Picciotto said.
The study was published today in the journal Science.
by: Joseph Brownstein, MyHealthNewsDaily
from:weight loss
Tidak ada komentar:
Posting Komentar