Rabu, 22 Juni 2011

Obesity surgery results in notes on weight loss secrets (LiveScience.com)

Surgery, obesity began with a simple premise: If you make the stomach smaller, people are eating less, so that they will lose weight.

But in recent years, the obesity surgery results were so outstanding, researchers went back to the drawing boards to find out what was going on.

Their results start to present a much more complicated picture of weight - and how much of the diet and exercise really can do to change it. It turned out a whole bunch of hormones from intestine and your communication with the brain play a role in the way of the body manages and loses weight.

Hunting after the answer to exactly how obesity surgery work provides new insights into human loss and appetite weight management, say the researchers.

"Due to the weight loss surgery, we finally begin to understand the physiology of weight-loss-better, as we prefer, have always understood", said Dr. Sunil Bhoyrul, a weight loss surgeon at the Olde del Mar surgical in La Jolla, California.

Their research to discover how the results of the operation to replicate that patients under the knife.

Ghrelin from intestine

There are different types of weight loss surgery (also known as bariatric surgery), including gastric bypass and gastric banding, but all make the stomach include smaller. [INFOGRAPHIC: types of weight loss surgery].

Patients may lose up to 60 80 percent of overweight in up to four years after surgery, and many keep an easier time have, as it through diet, Bhoyrul said. But can up to one third of a back seven weight on their intervention until 10 years later, at the end he known.

But researchers are realizing these weight loss after surgery fundamentally is realized by weight-loss diet.

A key player in this difference is the hormone ghrelin, which stimulates appetite. If we diet, make our ghrelin levels rise, us too hungry. We lose weight, but our ghrelin levels remain high, and we feel hungry also after meal. Ghrelin levels come only when we said the weight again Dr. Robin Blackstone, bariatric surgeon Scottsdale Bariatric Center in Arizona.

"People are trying to lose to keep tooth and nail by the body weight that weight to be fought", Dr. Miguel Burch, Associate Director of general surgery and minimally invasive surgery at Cedars-Sinai said Medical Center in Los Angeles.

But after gastric bypass surgery, ghrelin, Burch said, levels.

"they lose more weight than she ever had and not only are not hungry, they have to eat," said Burch. This his can, why op patients can keep their weight, he said.

And ghrelin is probably just the tip of the iceberg of the hormonal changes that occur. There are probably many more hormones that we do not know after the operation of this aid in weight loss, Burch said.

However, of stomach

Results of the operation have also made it clear, the role of the brain in weight loss and weight gain. Their opinion, not only in your stomach, manages your waist.

"We never realized that the brain was so important," said Bhoyrul. "We thought that it was just as simple as always people of to less food." The least problems turns, ", he said."

The brain is the body's energy thermostat, Bhoyrul taxes said, how quickly you use energy, and when you save and spend it. There is an ongoing conversation between gut and brain, which takes place on hormones, he said.

Decryption understand this conversation researchers, instigate such as best weight loss could help Bhoyrul said.

The last statement underscores how much is it to learn, the stomach-brain connection. Seen in contrast to the declining ghrelin after gastric bypass said those who undergo gastric banding a drop experience in their hunger, but not in ghrelin, Dr. Emma Patterson, a bariatric surgeon in Portland, Oregon/United States may be this, for ghrelin to otherwise communicate with the brain after this operation, Patterson said.

Surgery without surgery

It would be possible to replicate the results of the operation with drugs.

"If we understand how these operations Work…we can use what is always the thing in a pill," Patterson said.

A possible target might be an enzyme, that the production of ghrelin, said Burch.

In fact, an approach attempted by researchers, an obesity vaccine to develop to block hormone production.

However, some have argued that, because many hormones in losing weight are involved, not to help, on a weight to lose is.

"Most of us are skeptical that 'ghrelin twirling button' is the universal answer to all obesity," said Bhoyrul.

Weitersagen: The success of obesity surgery is understanding as good hormones and the brain weight and controls regulate appetite give way.

This story was provided by MyHealthNewsDaily, a sister LiveScience site. MyHealthNewsDaily staff writer Rachael Rettner follow on Twitter @ RachaelRettner.


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